Targeting histone acetylation/deacetylation in parasites: an update (2017-2020).

摘要: Abstract Histone modifying enzymes have vital roles in the growth and survival of both parasites humans. Targeting epigenome can be a new strategy for treatment parasitic diseases. Compounds modulating histone acetylation/deacetylation recently been reported hampering Plasmodium, Schistosoma, Leishmania, Trypanosoma infections. Beside deacetylase inhibitors, PfGCN5 bromodomain inhibitors described to inhibit Plasmodium proliferation. Sm 8 SmSIRT2, as well Leishmania sirtuins (SIR2rps), seem most reliable targets effectively fight related protozoan The selectivity toward parasite over mammalian cells is still an open question, significant optimization efforts epidrugs are required improve potency/selectivity decrease toxicity. Recent reports on alteration cellular signaling pathways provoked by parasite infection through changes host status at gene promoters may suggest novel therapeutic strategies treat these