Growth retardation: use of sulfation factor as a bioassay for growth hormone.

摘要: A bioassay for measurement of human growth hormone based upon the observation that normal serum, in vitro, will favor incorporation S-35 into immature rat cartilage is described. The factor serum called "sulfation factor." Sulfation determinations were performed on 27 children, 15 with hypopituitarism, 26 dwarfs without demonstrable endocrine or other diseases, 11 children a variety non-pituitary diseases causing dwarfism, and 1 adult acromegaly. mean activity (± S. E.) sulfation was 0.84 ± 0.057 F. units 0.45 0.024 idiopathic hypopituitary patients (p There an excellent correlation between laboratory pituitary function. Hypophysectomized rats receiving bovine showed substantial increase as compared to control hypophysectomized rats. appears be valid useful indicator serum.