Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier.

摘要: Recombinant human bone morphogenetic protein-2 was evaluated in maxillary alveolar clefts 24 adult, skeletally mature Foxhound dogs. Bilateral were prepared, 1 cm bony width, lined with healthy epithelium functional teeth on each side, and expected not to heal spontaneously new bone. Preparation of bilateral dogs permitted 48 recipient sites divided evenly among four treatment two time periods (2 4 months), yielding six replicates per time. The overall goal for the study regenerate cleft using one three treatments: (2) 200 microgram recombinant combined copolymer poly(lactide-co-glycolide) autogenous blood, or (3) an autograft from posterior iliac crest. A fourth group consisted untreated defects. At designated times, euthanized, beds contiguous recovered, processed, assessed radiographically histologically. Autograft-treated defects had more than other treatments at 2 months; however, by months, there no differences treatments, except group, which least amount Response may have been suboptimal either because dose too low poly(lactide-co-glycolide)-autogenous blood delivery system did temporally maintain spatially position bed. In addition, development a nonhealing, critical-sized defect maxilla dog appears require aggressive resection preclude spontaneous osseous regeneration.