The role of mouse tumour models in the discovery and development of anticancer drugs.

摘要: Our understanding of cancer biology has increased substantially over the past 30 years. Despite this, and an increasing pharmaceutical company expenditure on research development, approval novel oncology drugs during decade continues to be modest. In addition, attrition agents clinical development remains high. This can attributed, at least in part, being underpinned by demonstration predictable efficacy experimental models human tumours. review will focus range available for discovery anticancer drugs, from traditional subcutaneous injection tumour cell lines mice genetically engineered spontaneously give rise It consider best time use models, along with practical applications shortcomings. Finally, most importantly, it describe how these reflect underlying well they predict clinic. Developing a line sight clinic early drug project provides clear benefit, as helps guide selection appropriate preclinical facilitates investigation relevant biomarkers.