The Quest for Anti-inflammatory and Anti-infective Biomaterials in Clinical Translation

摘要: Biomaterials are now being used or evaluated clinically as implants to supplement the severe shortage of available human donor organs. To date however, such have mainly been developed scaffolds promote regeneration failing organs due old age congenital malformations. In real world, infection immunological issues often compromise patients. For example, bacterial and viral infections can result in uncontrolled immunopathological damage lead organ failure. Hence, there is a need for biomaterials that not only but also address specific compromised patients inflammation. Different strategies needed damaged by inflammation successful clinical translation. Therefore, quest multi-functional with combined properties combat infections, modulate at same time. These will necessitate inclusion methodologies management cellular signaling components elicited within local microenvironment. development biomaterials, range from materials intrinsic anti-inflammatory properties, synthetic lipid polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC), silver nanoparticles anti-bacterial nano- micro-particles composites deliver active drugs. this present review, we examples both kinds each group along their pros cons. Thus, promising next generation strategy aid replace tissue/organ transplantation, an integrated smart programmable platform regenerative medicine applications create and/or restore normal function cell tissue levels. it utmost important develop integrative based on biopolymers nanosystem practical