RAB22A overexpression promotes the tumor growth of melanoma

摘要: // Feng Su 1 , Yifei Chen 2 Shilin Zhu 3 Fangfang Li 4, 5 Shuang Zhao Lisa Wu 6 Xiang Juan Department of Emergency, Xiangya Hospital, Central South University, Changsha, China Pharmacy, Hunan, Neurology, The Second Affiliated Hospital Hunan University TCM, 4 Dermatology, Key Laboratory Skin Cancer and Psoriasis, Institute Medical Science Research, Correspondence to: Su, email: sujuanderm@csu.edu.cn Keywords: melanoma, RAB22A, prognosis, malignant phenotype, microRNA Received: July 25, 2016      Accepted: September 22, Published: 28, 2016 ABSTRACT Malignant melanoma is the most aggressive type skin cancer. a member RAS oncogene family, has been found to be significantly upregulated in multiple human cancers. In present study, we that RAB22A mRNA expression was tissues (including 60 primary melanomas 84 metastatic melanomas) compared benign nevi ( n = 20), which were higher than tissues. Immunohistochemistry data further showed positive immunoreactivity detected 66% (95/144) tissues, but not nevi. Moreover, high associated with advanced clinical stage melanoma. Furthermore, patients had shorter overall survival those low RAB22A. In-vitro study also cell lines WM35, A375, WM451, SK-MEL-1, when normal melanocyte HM cells. Knockdown reduced proliferation, migration invasion A375 cells, while overexpression promoted these phenotypes. addition, target miR-203, tumor suppressive miRNA Besides, miR-203 downregulated lines, respectively. Taken findings together, our could validate an oncogenic role suggesting may potential therapeutic for