Adjustable degradation and drug release of a thermosensitive hydrogel based on a pendant cyclic ether modified poly(ε-caprolactone) and poly(ethylene glycol)co-polymer

作者: Weiwei Wang , Liandong Deng , Shasha Liu , Xu Li , Xiumei Zhao

DOI: 10.1016/J.ACTBIO.2012.07.021

关键词: PolyesterNanoparticleEthylene glycolChemical engineeringSelf-healing hydrogelsPolymer chemistryDrug deliveryCopolymerCaprolactoneMaterials scienceIn vivo

摘要: … for injectable hydrogel formulations in clinical applications. Here a new … thermosensitive hydrogel formed from poly(ε-caprolactone) (PCL)–poly(ethylene glycol)–poly(ε-caprolactone) …

参考文章(45)
Byeongmoon Jeong, You Han Bae, Doo Sung Lee, Sung Wan Kim, Biodegradable block copolymers as injectable drug-delivery systems Nature. ,vol. 388, pp. 860- 862 ,(1997) , 10.1038/42218
Zhenqing Li, Jianjun Guan, Thermosensitive hydrogels for drug delivery Expert Opinion on Drug Delivery. ,vol. 8, pp. 991- 1007 ,(2011) , 10.1517/17425247.2011.581656
Chao Zhang, Nivedita Sangaj, Yongsung Hwang, Ameya Phadke, Chien-Wen Chang, Shyni Varghese, Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering. Acta Biomaterialia. ,vol. 7, pp. 3362- 3369 ,(2011) , 10.1016/J.ACTBIO.2011.05.024
Yu Liu, Wan-Liang Lu, Jian-Cheng Wang, Xuan Zhang, Hua Zhang, Xue-Qing Wang, Tian-Yan Zhou, Qiang Zhang, Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic® F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization Journal of Controlled Release. ,vol. 117, pp. 387- 395 ,(2007) , 10.1016/J.JCONREL.2006.11.024
Guangtao Chang, Tianyuan Ci, Lin Yu, Jiandong Ding, Enhancement of the fraction of the active form of an antitumor drug topotecan via an injectable hydrogel Journal of Controlled Release. ,vol. 156, pp. 21- 27 ,(2011) , 10.1016/J.JCONREL.2011.07.008
Byeongmoon Jeong, You Han Bae, Sung Wan Kim, Drug release from biodegradable injectable thermosensitive hydrogel of PEG–PLGA–PEG triblock copolymers Journal of Controlled Release. ,vol. 63, pp. 155- 163 ,(2000) , 10.1016/S0168-3659(99)00194-7
Tomomi Tanigo, Ryohei Takaoka, Yasuhiko Tabata, Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration. Journal of Controlled Release. ,vol. 143, pp. 201- 206 ,(2010) , 10.1016/J.JCONREL.2009.12.027
Gaurav Bajaj, Mi Ran Kim, Sulma I. Mohammed, Yoon Yeo, Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors Journal of Controlled Release. ,vol. 158, pp. 386- 392 ,(2012) , 10.1016/J.JCONREL.2011.12.001
Dai P. Huynh, Minh K. Nguyen, Bong S. Pi, Min S. Kim, Su Y. Chae, Kang C. Lee, Bong S. Kim, Sung W. Kim, Doo S. Lee, Functionalized injectable hydrogels for controlled insulin delivery Biomaterials. ,vol. 29, pp. 2527- 2534 ,(2008) , 10.1016/J.BIOMATERIALS.2008.02.016