Replication stress links structural and numerical cancer chromosomal instability
作者： Rebecca A. Burrell , Sarah E. McClelland , David Endesfelder , Petra Groth , Marie-Christine Weller
DOI: 10.1038/NATURE11935
关键词: DNA replication 、 Gene 、 Biology 、 Chromosome segregation 、 Aneuploidy 、 Chromosome instability 、 DNA damage 、 Genetics 、 Mitosis 、 Chromosome
摘要: … a major driver of chromosomal instability in CRC. In … DNA damage and structurally abnormal chromosomes that missegregate during mitosis, linking structural and numerical instability. …
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