Glucose Disposal is Not Proportional to Plasma Glucose Level in Man

摘要: Metabolic clearance rate (MCR) of glucose has been defined as the utilization divided by concentration. This model transport widely used a measure hormonally regulated disposal, on assumption that disposal is proportional to To test this assumption, relationship between concentration and was studied in man during infusion somatostatin ± exogenous insulin achieve fixed plasma levels 1,18, 46 μU/ml separate days. When increased more than twice basal fasting levels, significantly at all three levels. However, increase not rise concentration, MCR fell 38%, 16%, 11% low, medium, high respectively. These results are explained an alternative which insulin-independent tissues such brain have relatively uptake, while other systems take up its We conclude good because it partially dependent particularly low