Regulation of mice liver regeneration by early growth response-1 through the GGPPS/RAS/MAPK pathway.
作者： Shanshan Lai , Jun Yuan , Dandan Zhao , Ning Shen , Weibo Chen
DOI: 10.1016/J.BIOCEL.2015.04.003
关键词: Cell biology 、 Cyclin D1 、 Cell growth 、 Transcription factor 、 Biology 、 MAPK/ERK pathway 、 Cyclin E 、 Molecular biology 、 Signal transduction 、 Liver regeneration 、 Proliferating cell nuclear antigen
摘要: Abstract Background & Aims Liver regeneration (LR) consists of a series of complicated processes in which several transcription factors play important roles. Among them, the early growth response 1 gene (EGR-1) is rapidly induced in response to liver resection. Previous studies have shown that EGR-1−/− mice exhibit delayed hepatocellular mitotic progression after partial hepatectomy (PH). The mechanism underlying the EGR-1 regulated LR is still unknown. Our aim is to elucidate the underlying mechanism. Methods Mice infected with …
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