作者: Paul Benjamin Loughrey , Dongyun Zhang , Anthony P. Heaney
DOI: 10.1016/J.ECL.2018.04.014
关键词: Medicine 、 Cancer research 、 Carcinoid syndrome 、 Sunitinib 、 Embolization 、 Neuroendocrine tumors 、 Radionuclide therapy 、 Symptom relief 、 Everolimus 、 Telotristat Etiprate
摘要: Neuroendocrine tumors, including carcinoids, are rare and insidiously growing tumors. Related to their site of origin, tumors can be functional, causing various forms the carcinoid syndrome, owing overproduction serotonin, histamine, or other bioactive substances. They often invade adjacent structures metastasize liver elsewhere. Treatment includes multimodal approaches, cytoreductive surgery, locoregional embolization, cytotoxic therapy, peptide receptor radionuclide targeted therapies with goals symptom relief control tumor growth. This article summarizes current emerging approaches management reviews several promising future therapies.