Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.
作者： J Leonard , B Peers , T Johnson , K Ferreri , S Lee
DOI: 10.1210/MEND.7.10.7505393
关键词: Somatostatin receptor 1 、 Molecular biology 、 Somatostatin 、 Pancreas 、 Somatostatin receptor 、 Enteroendocrine cell 、 Somatostatin receptor 2 、 Biology 、 Delta cell 、 Somatostatin receptor 3
摘要: The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression peptide hormones such as insulin, glucagon, and somatostatin. Although a number homeobox-type factors have been proposed key regulators individual genes in the pancreas, cellular distribution relative abundance remain uncharacterized. Also, overlapping DNA binding specificities further obscured regulatory functions these perform during development. In this report we characterize novel somatostatin transactivating factor termed STF-1, which is uniformly expressed cells small intestine. 283-amino acid STF-1 protein binds to tissue-specific elements within promoter stimulates gene both vivo vitro. Remarkably, comprises predominant element-binding activity nuclear extracts from somatostatin-producing pa...
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