Immunology and Immunotherapy of Head and Neck Cancer

摘要: The immune system plays a key role in the development, establishment, and progression of head neck squamous cell carcinoma (HNSCC). A greater understanding dysregulation evasion evolution HNSCC provides basis for improved therapies outcomes patients. cells evade host through manipulation their own immunogenicity, production immunosuppressive mediators, promotion immunomodulatory types. Through tumor's influence on microenvironment, can be exploited to promote metastasis, angiogenesis, growth. This article brief overview components infiltrating tumor reviewing immunological principles related cancer, including concept cancer immunosurveillance escape. Current immunotherapeutic strategies emerging results from ongoing clinical trials are presented.