Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
作者： Heiko Sommer , Ilan Marek
DOI: 10.1039/C8SC02085J
关键词: Derivative (chemistry) 、 Ligand 、 Combinatorial chemistry 、 Copper catalyzed 、 Copper hydride 、 Enantioselective synthesis 、 Chemistry 、 Xantphos 、 Electrophile
摘要: A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. variety allyl electrophiles could be utilized yielding a diverse range trisubstituted cyclopropanes. Finally preliminary variant established employing recently described P-stereogenic xantphos derivative as ligand.
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