Low nanogram per liter determination of halogenated nonylphenols, nonylphenol carboxylates, and their non-halogenated precursors in water and sludge by liquid chromatography electrospray tandem mass spectrometry

摘要: A new LC-MS-MS method for quantitative analysis of nonylphenol (NP), carboxylates (NPECs), and their halogenated derivatives: brominated chlorinated nonylphenols (BrNP, ClNP), (BrNPE1C ClNPE1C) ethoxycarboxylates (BrNPE2C ClNPE2C) in water sludge has been developed. Electrospray negative ionization MS-MS was applied the identification above mentioned compounds. Upon collision-induced dissociation, deprotonated molecules gave different fragments formed by cleavage alkyl moiety and/or (ethoxy)carboxylic moiety. For compounds a highly diagnostic characteristic pattern isotopic doublet signals obtained fragmentation yielded, addition to ions, [Br]− [Cl]−, respectively. Quantitative done multiple reaction monitoring (MRM) mode, using two specific combinations precursor-product ion transitions each compound. Additionally, channels transition reaction, corresponding isotopes, were monitored ratio abundances used as an criterion. The validated terms sensitivity, selectivity, accuracy, precision samples from drinking treatment plant (DWTP) Barcelona (Catalonia, NE Spain). Halogenated NP NPECs detected prechlorinated concentrations up 315 ng/L, BrNPE2C being most abundant In DWTP effluent non-halogenated at trace levels (85, 12 10 ng/L NP, NPE1C, NPE2C, respectively), whereas concentration derivatives never exceeded ng/L. Nonylphenol, NPs found flocculation 150, 105, 145 µg/kg, Acidic polar metabolites lower 20 µg/kg.