p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

摘要: Background. Indoxyl sulphate (IS) and p-cresyl (PCS) are uraemic toxins that have similar protein binding, dialytic clearance proinflammatory features. However, only a few prospective studies evaluated possible associations between these two retained solutes renal disease progression in chronic kidney (CKD) patients. Methods. This observational study independent serum total IS PCS with selected cohort of patients having different stages CKD. Baseline were correlated [defined as decrements estimated glomerular filtration rate (eGFR) > 50% from baseline or to end-stage (ESRD)] death during follow-up period 24 months. Results. Of 268 patients, 35 (13.1%) had 14 (5.2%) died after mean 21 ± 3 months. Univariate Cox regression analysis followed by multivariate showed high-serum levels associated all-cause mortality age, gender, diabetes status, albumin levels, IS, creatinine, Ca × P product, intact parathyroid hormone, haemoglobin high-sensitivity C-reactive level. Serum was progression; however, the predictive power weakened when also present analytical model. Conclusions. In addition traditional uraemia-related risk factors such function, may help predicting