Myelin plasticity in the central nervous system.

作者: David Purger , Erin M. Gibson , Michelle Monje

DOI: 10.1016/J.NEUROPHARM.2015.08.001

关键词: ZebrafishMyelinNeuroscienceCellular differentiationBiologyNeuroplasticityPremovement neuronal activityOligodendrocyteCentral nervous systemSaltatory conduction

摘要: Myelin sheaths, specialized segments of oligodendrocyte (OL) plasma membranes in the central nervous system (CNS), facilitate fast, saltatory conduction action potentials down axons. Changes to fine structure myelin a neural circuit, including sheath thickness and internode length (length between nodes Ranvier), are expected affect velocity potentials. Myelination mammalian CNS occurs stereotyped, progressive pattern continues well into adulthood humans. Recent evidence from zebrafish, rodents, non-human primates, humans suggests that myelination may be sensitive experiences during development adulthood, varying levels neuronal activity underlie these experience-dependent changes myelin-forming cells. Several cellular, molecular, epigenetic mechanisms have been investigated as contributors plasticity. A deeper understanding plasticity its underlying provide insights diseases involving damage or dysregulation. This article is part Special Issue entitled 'Oligodendrocytes Health Disease'.

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