作者: Marijke A. de Vries , Boudewijn Klop , Hans W. Janssen , Tjin L. Njo , Elsbeth M. Westerman
DOI: 10.1007/978-3-319-07320-0_12
关键词: Postprandial 、 Biology 、 Endothelial dysfunction 、 Glycation 、 Integrin 、 Internal medicine 、 Chylomicron 、 Inflammation 、 Oxidative stress 、 Complement system 、 Endocrinology
摘要: Many risk factors have been identified as being responsible for the process of atherogenesis. Several these are related to inflammation, which is an obligatory feature atherosclerotic plaque. Increasing evidence suggests that postprandial lipoproteins and glucose may be involved in inflammatory preceding development atherosclerosis. During situation, remnants chylomicrons very low-density bind circulating leukocytes endothelial cells, leading a state acute activation with expression integrins on different generation oxidative stress, production cytokines complement activation. Elevated plasma levels also induce leukocyte humans. In addition, advanced glycation end products, formed during hyperglycemia, cause inflammation damage. This chain events results situation causing dysfunction, one earliest defects Interestingly, while this occur several times each day after meal, there only limited information contribution nutrients processes. review, we will focus available discuss role lifestyle pharmaceutical interventions modulating inflammation.