Marked differences in differentiation propensity among human embryonic stem cell lines
作者： Kenji Osafune , Leslie Caron , Malgorzata Borowiak , Rita J Martinez , Claire S Fitz-Gerald
DOI: 10.1038/NBT1383
关键词: Cell biology 、 Gene expression 、 Cell culture 、 Cardiomyocyte generation 、 Biology 、 Pancreatic differentiation 、 Embryonic stem cell 、 Genetics
摘要: The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic and 3 cardiomyocyte generation. These non-trivial developmental among hES point the importance screening deriving differentiation.
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