Risk factors for age-related cataract : A prospective cohort study

摘要: Cataract is the most common cause of blindness in world. Epidemiologic studies have shown that etiology cataract multifactorial. increases with age and oxidative damage to lens proteins suggested be importance. The only currently available treatment surgical extraction lens; two thirds these operations are performed women. Today Sweden operation, nearly 80,000 being each year among a population 9 million inhabitants. number extractions has increased dramatically during last decades due improvements operation technique leading earlier intervention, an increasing elderly population. involves decreased vision deteriorated quality life resulting socio-economic consequences. Elderly individuals compromised require assistance. Furthermore, expenses increase rise volumes. Therefore, finding modifiable risk factors for public health Cigarette smoking, UV-exposure, diabetes steroid medication been associated previous studies. Alcohol consumption, abdominal adiposity, hypertension postmenopausal hormone therapy may development. Dietary patterns vitamin supplement use could also aim this thesis was investigate association between smoking intensity; cessation; alcohol consumption; metabolic syndrome its components hypertension; therapy, incidence age-related women Swedish Mammography Cohort (SMC). About 35,000 cohort (born 1914-48) living Vastmanland Uppsala county, filled mailed questionnaire on diet, height, weight lifestyle 1997. During study period, September 1997 until October 2005, total 4,508 incident cases were identified by linking cohort, using personal identification number, computerized registers counties. Cox proportional hazards models used estimate relative as rate ratio (RR) 95% confidence interval (CI) adjusted potential confounders. Smoking 17 % significant dose-response intensity , measured average cigarettes smoked per day life-time. Quitting predicted reduced over time, but longer time needed those higher intensity. consumption modest (10%) extraction. consumption. An increment 1 alcoholic drink (equivalent 13 gram day), 7% Women who well had five years than did neither. Abdominal adiposity (waist circumference 80 cm), positively extraction, observed 8 %, 43 12 respectively. all three component even greater (68%); younger 65 almost 3 fold syndrome. Current replacement (HRT) 18% duration HRT use. users consuming more one (42%) In conclusion, healthy life-style promotions like prevention or cessation, control, restrictive HRT, delay development cataract. LIST OF PUBLICATIONS This based following papers, which will referred text their Roman numerals: I. Ejdervik Lindblad B, Hakansson N, Svensson H, Philipson Wolk A. Intensity cessation relation extraction: A prospective Am J Epidemiol 2005;162:73-79. II. Ophthalmology 2007;114:680-5. III. Metabolic 2008;115:1687-92. IV. Hormone (Submitted)