Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas
作者： JIA LI , ER-BAO BIAN , XIAO-JUN HE , CHUN-CHUN MA , GANG ZONG
关键词: Methylation 、 Downregulation and upregulation 、 DNA methylation 、 Regulation of gene expression 、 Epigenetics 、 Glioma 、 Cancer research 、 Biology 、 Epigenetic Repression 、 MEG3
摘要: Epigenetic regulation plays a significant role in gliomas. However, how methylation and long non-coding RNA (lncRNA) cooperates to regulate gliomas progression is largely unknown. In this investigation we showed that the downregulation of MEG3 expression due hypermethylation was observed tissues. Treatment glioma cells with DNA inhibitor 5-Aza-2'-deoxycytidine (5-AzadC) decreased aberrant promoter prevented loss expression. addition, DNMT1 involved methylation, inversely correlated The inhibition repressed proliferation, clone formation, induced apoptosis cells. Importantly, contributed activation p53 pathways These results suggest DNMT1-mediated caused expression, followed by
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