Toward the Identification of Extra-Oral TAS2R Agonists as Drug Agents for Muscle Relaxation Therapies via Bioinformatics-Aided Screening of Bitter Compounds in Traditional Chinese Medicine
作者： Mingzhi Luo , Kai Ni , Yang Jin , Zifan Yu , Linhong Deng
关键词: Relaxation (psychology) 、 Drug 、 Bioinformatics software 、 Traditional Chinese medicine 、 Myocyte 、 Medicine 、 Identification (biology) 、 Muscle relaxation 、 Taste 、 Bioinformatics
摘要: … It is shown that 16 of 25 TAS2Rs have natural agonists from bitter flavored TCM. Among them, TAS2R10, 14, 39, 46 can be activated by more than 20 bitter components from bitter …
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sci-hub.se 参考文章(117)
Wolfgang Meyerhof, Elucidation of mammalian bitter taste Reviews of Physiology Biochemistry and Pharmacology. ,vol. 154, pp. 37- 72 ,(2005) , 10.1007/S10254-005-0041-0
Joshua N. Fletcher, Li Pan, A. Douglas Kinghorn, Medicinal Chemistry of Plant Naturals as Agonists/Antagonists for Taste Receptors Springer, Cham. pp. 35- 71 ,(2014) , 10.1007/7355_2014_81
Marilena Gilca, Alina Barbulescu, Taste of medicinal plants: A potential tool in predicting ethnopharmacological activities? Journal of Ethnopharmacology. ,vol. 174, pp. 464- 473 ,(2015) , 10.1016/J.JEP.2015.08.040
Christian W Gruber, Margaret O'Brien, Uterotonic plants and their bioactive constituents. Planta Medica. ,vol. 77, pp. 207- 220 ,(2011) , 10.1055/S-0030-1250317
A. Brockhoff, M. Behrens, N. Roudnitzky, G. Appendino, C. Avonto, W. Meyerhof, Receptor Agonism and Antagonism of Dietary Bitter Compounds The Journal of Neuroscience. ,vol. 31, pp. 14775- 14782 ,(2011) , 10.1523/JNEUROSCI.2923-11.2011
Simon R Foster, Eugeni Roura, Walter G Thomas, None, Extrasensory perception: Odorant and taste receptors beyond the nose and mouth Pharmacology & Therapeutics. ,vol. 142, pp. 41- 61 ,(2014) , 10.1016/J.PHARMTHERA.2013.11.004
Maik Behrens, Wolfgang Meyerhof, Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs Seminars in Cell & Developmental Biology. ,vol. 24, pp. 215- 221 ,(2013) , 10.1016/J.SEMCDB.2012.08.006
Takanobu Sakurai, Takumi Misaka, Masaji Ishiguro, Katsuyoshi Masuda, Taishi Sugawara, Keisuke Ito, Takuya Kobayashi, Shinji Matsuo, Yoshiro Ishimaru, Tomiko Asakura, Keiko Abe, Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16 Journal of Biological Chemistry. ,vol. 285, pp. 28373- 28378 ,(2010) , 10.1074/JBC.M110.144444
Thijs Beuming, Woody Sherman, Current Assessment of Docking into GPCR Crystal Structures and Homology Models: Successes, Challenges, and Guidelines Journal of Chemical Information and Modeling. ,vol. 52, pp. 3263- 3277 ,(2012) , 10.1021/CI300411B
A. Brockhoff, M. Behrens, M. Y. Niv, W. Meyerhof, Structural requirements of bitter taste receptor activation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 11110- 11115 ,(2010) , 10.1073/PNAS.0913862107