Aptamer-conjugated Mn3O4@SiO2 core–shell nanoprobes for targeted magnetic resonance imaging
作者： He Hu , Antao Dai , Jin Sun , Xiangyuan Li , Fenghou Gao
DOI: 10.1039/C3NR03490A
关键词: Materials science 、 Transplantation 、 Biocompatibility 、 Biophysics 、 Nanotechnology 、 Aptamer 、 Fluorophore 、 Biodistribution 、 Conjugated system 、 Ethylene glycol 、 Rhodamine
摘要: The objective of this study was to evaluate the targeted T1-magnetic resonance imaging (MRI), quantitative biodistribution and toxicity aptamer (AS411) conjugated Mn3O4@SiO2 core–shell nanoprobes (NPs) in human cervical carcinoma tumor-bearing mice. NPs were firstly prepared by encapsulating a hydrophobic Mn3O4 core within an amino functionalized silica shell. fluorophore rhodamine (RB) doped into shell amphiphilic polymer poly(ethylene glycol) (PEG) modified on surface improve its biocompatibility, then AS411 onto end PEG chains as targeting ligands. final abbreviated Mn3O4@SiO2(RB)–PEG–Apt. By means vitro fluorescence confocal vivo MRI, have been demonstrated target cancer cells prominent tumor aggregation effectively. results further confirmed study. In addition, histological, hematological biochemistry analysis also proved low vivo. Our showed great potential Mn3O4@SiO2(RB)–PEG–Apt could be used multifunctional nanoplatform for long-term therapy cancer.
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