Coronary thrombolysis during acute myocardial infarction by intravenous BRL 26921, a new anisoylated plasminogen-streptokinase activator complex
作者： Wolfgang Kasper , Thomas Meinertz , Helmut Wollschläger , Tassilo Bonzel , Paul Wolff
DOI: 10.1016/0002-9149(86)90006-8
关键词: Cardiology 、 Activator (genetics) 、 Plasminogen activator 、 Internal medicine 、 Chemotherapy 、 Streptokinase 、 Bolus injection 、 Hypofibrinogenemia 、 Myocardial infarction 、 Artery 、 Medicine
摘要: Abstract The safety and fibrinolytic efficacy of a new anisoylated plasminogen-streptokinase activator complex (APSAC) was tested in 50 patients with acute myocardial infarction (AMI) less than 4 hours duration. APSAC (30 mg) given intravenously as bolus injection 151 ± 47 minutes after clinical symptoms. Coronary angiography then performed to assess coronary artery patency: 28 had an inferior AMI 22 anterior AMI. A patent infarct-related found 32 (64%) on first 66 21 administration APSAC. Subsequent reperfusion observed 10 74 16 (84%). Bleeding complications or hematomas were 18 patients, whom 3 required blood transfusions. Marked hypofibrinogenemia within 24 most patients. control angiogram recorded 37 (74%) 25 19 days showed reocclusion 5
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