In vitro ageing of pig oocytes: effects of the histone deacetylase inhibitor trichostatin A.
作者： M. Ješeta , J. Petr , T. Krejčová , E. Chmelíková , F. Jílek
DOI: 10.1017/S0967199408004668
关键词: HDAC11 、 In vitro maturation 、 Histone deacetylase 2 、 Chemistry 、 Andrology 、 Histone deacetylase 5 、 Oocyte 、 Trichostatin A 、 Blastocyst 、 Histone deacetylase inhibitor
摘要: After in vitro maturation, the unfertilized pig oocytes underwent process called ageing. This involves typical events such as fragmentation, spontaneous parthenogenetic activation or lysis. Inhibition of histone deacetylase, using its specific inhibitor trichostatin A (TSA), significantly delayed maturation cultured vitro. The ageing matured under effect TSA is same without TSA. inhibition deacetylase during oocyte reduced percentage fragmented (from 30% untreated to 9% aged 100 nM TSA). Oocytes and subsequently for 1 day effects retained their developmental capacity. activation, a higher portion (27% vs. 15%) developed blastocyst stage after 24 h when compared with activated TSA-free medium. development treatment similar fresh (29% blastocyst) artificially immediately maturation.
sci-hub.se 参考文章(53)
Austin Cr, Ageing and reproduction: post-ovulatory deterioration of the egg. Journal of reproduction and fertility. ,vol. 12, pp. 39- 53 ,(1970)
Ernst Knobil, Jimmy D. Neill, The Physiology of reproduction Psychoneuroendocrinology. ,vol. 7, pp. 641- 642 ,(1988)
Michael J. Kruhlak, Wolfgang Fischle, Nicholas R. Bertos, Michael J. Hendzel, Shahid Hameed, Eric Verdin, David P. Bazett-Jones, Xiang-Jiao Yang, Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. Journal of Biological Chemistry. ,vol. 276, pp. 38307- 38319 ,(2001) , 10.1074/JBC.M100290200
J. M. Adams, The Bcl-2 Protein Family: Arbiters of Cell Survival Science. ,vol. 281, pp. 1322- 1326 ,(1998) , 10.1126/SCIENCE.281.5381.1322
Steven L. Stice, Carol L. Keefer, Lee Matthews, Bovine nuclear transfer embryos: Oocyte activation prior to blastomere fusion Molecular Reproduction and Development. ,vol. 38, pp. 61- 68 ,(1994) , 10.1002/MRD.1080380111
Qiang Wang, Chun-Min Wang, Jun-Shu Ai, Bo Xiong, Shen Yin, Yi Hou, Da-Yuan Chen, Heide Schatten, Qing-Yuan Sun, Histone Phosphorylation and Pericentromeric Histone Modifications in Oocyte Meiosis Cell Cycle. ,vol. 5, pp. 1974- 1982 ,(2006) , 10.4161/CC.5.17.3183
R.C. Chian, H. Nakahara, K. Niwa, H. Funahashi, Fertilization and early cleavage in vitro of ageing bovine oocytes after maturation in culture. Theriogenology. ,vol. 37, pp. 665- 672 ,(1992) , 10.1016/0093-691X(92)90146-I
Kazuhiro Kikuchi, Kunihiko Naito, Junko Noguchi, Arata Shimada, Hiroyuki Kaneko, Masakane Yamashita, Fugaku Aoki, Hideaki Tojo, Yutaka Toyoda, Maturation/M-phase promoting factor: a regulator of aging in porcine oocytes. Biology of Reproduction. ,vol. 63, pp. 715- 722 ,(2000) , 10.1095/BIOLREPROD63.3.715
A Jurisicova, H-J Lee, S G D'Estaing, J Tilly, G I Perez, Molecular requirements for doxorubicin-mediated death in murine oocytes Cell Death & Differentiation. ,vol. 13, pp. 1466- 1474 ,(2006) , 10.1038/SJ.CDD.4401819
Minoru Yoshida, Teruhiko Beppu, Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A. Experimental Cell Research. ,vol. 177, pp. 122- 131 ,(1988) , 10.1016/0014-4827(88)90030-4