Expression of Retroviral Sequences and Oncogenes in Murine Hepatocellular Tumors

摘要: The expression of endogenous retroviral sequences and three cellular oncogenes was examined in hepatocellular adenomas four carcinomas induced male C57BL/6JDp × C3Hf/Dp F1 (hereafter called B6C3F1) mice by a single dose nitrosodiethylamine, five that arose spontaneously C3Hf mice, the livers normal age-matched control mice. In all these carcinomas, there increased Moloney murine leukemia virus- intracisternal A particle-related sequences. retrovirus-like VL30 sequence expressed at significant levels liver this found only 4 12 tumors examined. Expression mouse mammary tumor virus-related not detected or any tumors. With respect to oncogenes, c- myc seen B6C3F1 Two samples displayed . There slight increase Ha-ras some Increased fos 1 Taken together, studies indicate both carcinogen-induced spontaneous formation is associated with abnormalities retrovirus-related DNA also specific oncogenes.