The age-specific relationships of abnormal cytology and human papillomavirus DNA results to the risk of cervical precancer and cancer.

摘要: Background To estimate the relationship of human papillomavirus (HPV) detection and abnormal cytology with histologic diagnoses cervical precancer cancer. Methods From 2003 to 2008 we examined HPV, cytology, diagnostic results from almost one million cancer screenings done on women aged 30 older who were members in Kaiser Permanente Northern California, a large health maintenance organization that introduced cotesting 2003. Women screened using conventional Pap tests DNA test for pool 13 high-risk HPV genotypes. HPV-positive atypical squamous cells undetermined significance other independent their results, routinely underwent colposcopy. Results stratified by 5-year age groups 64. High-grade intraepithelial lesions (HSIL), cells, cannot exclude HSIL (ASC-H), glandular more strongly associated neoplasia grade 3 while low-grade (LSIL) 2 (CIN2). Cervical was most commonly found cytology. Human papillomavirus-negative ASC-H at reduced but significant risk CIN2 or severe (CIN2+) (10.6%) compared LSIL 4.0% CIN2+, among 50 older, 0.5% CIN2+ no cancers diagnosed. Conclusion testing may be useful triage colposcopic referral not any age. Level evidence II.