Squamous Cell Carcinoma “Transformation” Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas

摘要: The authors report two cases of epidermal growth factor receptor gene (EGFR)-mutant stage IV lung adenocarcinomas developing immunohistochemically proven squamous cell carcinoma (SCC) "transformation" concurrently with T790M EGFR mutation, leading to acquired resistance inhibitors. Moreover, the histologic change EGFR-mutant adenocarcinoma into SCC has been recently reported in literature. histological transformation appears as a novel mechanism TKI EGFR-mutated and it may be challenging for treatment.