Number and affinity of insulin receptors in intact human subjects

摘要: A simple model of the distribution and metabolism insulin in vivo has been evaluated using data from infusion into a group normal subjects. The major rate-limiting step for access to degradation pathways is assumed consist binding ligand single population receptor sites, except that provision made possibility linear non-receptor-mediated phenomenon negative cooperativity. shown accommodate non-linearity metabolism, allows, evaluation association dissociation constants provides first time an estimate total accessible number intact organism. For fasting man predicts 1.00 +/- 0.05 nmol sites/kg (mean SD).