Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

摘要: In the present study we used an adoptive transfer model with athymic nude mice to characterize T cells involved in initiating and mediating skin allograft rejection. It was found that rejection required of immunocompetent such reconstitution did not itself stimulate appearance derived from host. Reconstitution isolated populations Lyt-2+/L3T4- resulted rapid MHC class I-disparate allografts, whereas L3T4+/Lyt-2- II-disparate minor H-disparate allografts. By correlating these responses functional capabilities antigen-specific contained within reconstituting Lyt-2+ L3T4+ cell populations, it noted allografts were only rejected by that, as shown vitro assessment, both lymphokine-secreting Th lymphokine-responsive Tk specific for alloantigens graft. The ability two functionally distinct subsets interact vivo reject directly demonstrated H-Y-specific taking advantage fact are while H-Y Lyt-2+. Finally, importance interactions between Th/T-inducer killer (Tk)/T-effector observation normal B6 retain Qala Kbm6 because a selective deficiency cells, even though they contain T-effector when activated, able Thus, is neither unique specialized subset given Lyt phenotype, nor helper-independent effector so-called dual function capability. Rather, can be mediated collaborations T-inducer interacting express different phenotypes well antigen specificities.