Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes

摘要: It is widely believed that aging results from the accumulation of molecular damage, including damage DNA and mitochondria garbage both inside outside cell. Recently, this paradigm being replaced by “hyperfunction theory”, which postulates caused activation signal transduction pathways such as TOR (Target Rapamycin). These consist different enzymes, mostly kinases, but also phosphatases, deacetylases, GTPases, some other molecules cause overactivation normal cellular functions. Overactivation these sensory can senescence, age-related diseases, cancer, shorten life span. Here we review numerous very recent publications on role in diseases. As was emphasized author model”, many (or actually all) them play roles cancer. So “participants” pro-aging signaling are well acquainted to cancer researchers. A cancer-related journal Oncotarget perfect place for publication experimental studies, reviews perspectives, it bridge gap between