Human lymphocytes produce pro-opiomelanocortin gene-related transcripts. Effects of lymphotropic viruses.
作者： E L Oates , G P Allaway , G R Armstrong , R A Boyajian , J H Kehrl
DOI: 10.1016/S0021-9258(19)81472-2
关键词: Gene 、 Deltaretrovirus 、 Virus 、 Lymphocyte 、 Virology 、 Biology 、 Anterior pituitary 、 T cell 、 Peripheral blood mononuclear cell 、 Cell culture 、 Cell biology 、 Biochemistry 、 Molecular biology
摘要: Expression of the pro-opiomelanocortin (POMC) gene was examined in normal human lymphocytes and lymphocyte cell lines infected by lymphotropic viruses. POMC transcripts were detected using stringent RNA-RNA hybridizations. Low transcript levels found phytohemagglutinin-stimulated peripheral blood mononuclear cells tonsillar T B cells. The highest with Epstein-Barr virus (EBV). However, viruses did not have increased transcripts. an EBV-transformed line affected dexamethasone or corticotropin-releasing hormone, known regulators anterior pituitary expression. Therefore, it is possible that EBV infections could result abnormal
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