Soft tissue small round cell tumors: morphological parameters

作者: E S d'Amore , V Ninfo

DOI:

关键词: Soft Tissue NeoplasmRound cellPeripheral Primitive Neuroectodermal TumorSoft tissueBiologyPathologyDifferential diagnosisImmunohistochemistrySarcomaClinical significance

摘要: Soft tissue small round cell tumors (SRCTs) comprise a heterogeneous group of neoplasms that predominate in childhood and adolescence share similar morphological features, consisting dense cellular proliferation cells with primitive appearance. Rhabdomyosarcomas, peripheral neuroepitheliomas, Ewing's sarcomas, lymphomas/leukemias are the prototypic SRCT; other recently described should be added to list desmoplastic SRCT rhabdoid tumor soft tissues. In addition, several primary metastatic have occasionally been considered differential diagnosis SRCT. The precise identification given is important because its clinical relevance. However, it may difficult diagnostic criteria sometimes subtle histologic immunohistochemical features not specific and/or simulated by different types. We discuss clues our opinion most useful for their diagnosis, distinguishing between neuroepithelioma sarcoma, main pitfalls.

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