The Role of Chemokines in Mediating Graft Versus Host Disease: Opportunities for Novel Therapeutics
作者： Marina GM Castor , Vanessa Pinho , Mauro M Teixeira , None
关键词: Graft-versus-host disease 、 Major complication 、 Graft versus leukaemia 、 Context (language use) 、 Pathogenesis 、 Chemokine 、 Leukocyte Trafficking 、 Medicine 、 Inflammation 、 Immunology
摘要: Bone marrow transplantation (BMT) is the current therapy of choice for several malignancies and severe autoimmune diseases. Graft versus host disease (GVHD) major complication associated with BMT. T lymphocytes other leukocytes migrate into target organs during GVHD, become activated mediate tissue damage. Chemokines are well known inducers leukocyte trafficking activation contribute to pathogenesis GVHD. Here, we review animal models used study GVHD role chemokines in mediating damage these models. The molecules promoting potential beneficial effects graft, especially graft leukaemia, also discussed. Finally, various pharmacological strategies block chemokine system or downstream signalling events context
frontiersin.org
core.ac.uk
sci-hub.se 参考文章(67)
Kenneth R. Cooke, Werner Krenger, Geoff Hill, Thomas R. Martin, Lester Kobzik, Joanne Brewer, Raymond Simmons, James M. Crawford, Marcel R.M. van den Brink, James L.M. Ferrara, Host Reactive Donor T Cells Are Associated With Lung Injury After Experimental Allogeneic Bone Marrow Transplantation Blood. ,vol. 92, pp. 2571- 2580 ,(1998) , 10.1182/BLOOD.V92.7.2571
Mauro Martins Teixeira, Cristiana Couto Garcia, Remo Castro Russo, Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists? Current Opinion in Drug Discovery & Development. ,vol. 13, pp. 414- ,(2010)
Nicolai A. Kittan, Gerhard C. Hildebrandt, The chemokine system: a possible therapeutic target in acute graft versus host disease. Current Topics in Microbiology and Immunology. ,vol. 341, pp. 97- 120 ,(2010) , 10.1007/82_2010_23
Angela Panoskaltsis-Mortari, Robert M. Strieter, John R. Hermanson, Konstantin V. Fegeding, William J. Murphy, Catherine L. Farrell, David L. Lacey, Bruce R. Blazar, Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation. Blood. ,vol. 96, pp. 834- 839 ,(2000) , 10.1182/BLOOD.V96.3.834.015K39_834_839
Claudia Calcaterra, Lucia Sfondrini, Anna Rossini, Michele Sommariva, Cristiano Rumio, Sylvie Ménard, Andrea Balsari, Critical role of TLR9 in acute graft-versus-host disease. Journal of Immunology. ,vol. 181, pp. 6132- 6139 ,(2008) , 10.4049/JIMMUNOL.181.9.6132
Christian A. Wysocki, Susan B. Burkett, Angela Panoskaltsis-Mortari, Suzanne L. Kirby, Andrew D. Luster, Karen McKinnon, Bruce R. Blazar, Jonathan S. Serody, Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. Journal of Immunology. ,vol. 173, pp. 845- 854 ,(2004) , 10.4049/JIMMUNOL.173.2.845
Eileen McMahon, Glenn K. Matsushima, Sergio A. Lira, Donald N. Cook, Bruce R. Blazar, Jonathan S. Serody, Susan E. Burkett, Angela Panoskaltsis-Mortari, Judith Ng-Cashin, T-lymphocyte production of macrophage inflammatory protein-1α is critical to the recruitment of CD8+ T cells to the liver, lung, and spleen during graft-versus-host disease Blood. ,vol. 96, pp. 2973- 2980 ,(2000) , 10.1182/BLOOD.V96.9.2973.H8002973_2973_2980
Charles R. Mackay, Chemokines: immunology's high impact factors Nature Immunology. ,vol. 2, pp. 95- 101 ,(2001) , 10.1038/84298
M. J. Carlson, L. M. Fulton, J. M. Coghill, M. L. West, J. E. Burgents, Y. Wan, A. Panoskaltsis-Mortari, T. F. Tedder, B. R. Blazar, J. S. Serody, L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation. American Journal of Transplantation. ,vol. 10, pp. 2596- 2603 ,(2010) , 10.1111/J.1600-6143.2010.03319.X
Miho Sasaki, Hitoshi Hasegawa, Masashi Kohno, Atsushi Inoue, Mitsuko R. Ito, Shigeru Fujita, Antagonist of secondary lymphoid-tissue chemokine (CCR ligand 21) prevents the development of chronic graft-versus-host disease in mice. Journal of Immunology. ,vol. 170, pp. 588- 596 ,(2003) , 10.4049/JIMMUNOL.170.1.588