Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester.

摘要: We assessed the contribution of angiotensin-(1-7) [Ang-(1-7)] to captopril-induced cardiovascular protection in spontaneously hypertensive rats (SHRs) chronically treated with nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (SHR-l). (80 mg/L) administration for 3 weeks increased mean arterial pressure (MAP) from 196 ± 6 229 mm Hg (P < 0.05). Treatment SHR-l Ang-(1-7) antagonist [d-Ala7]-Ang-(1-7) (A779; 744 μg·kg(-1)·d(-1) ip) further elevated MAP 253 0.05 vs or SHR). Moreover, A779 treatment attenuated reduction and proteinuria by either captopril (300 mg/L drinking water) hydralazine (1.5 mg·kg(-1)·d(-1) ip). In isolated perfused hearts, recovery left ventricular function global ischemia was enhanced exacerbated A779. The beneficial effects on cardiac function. Recovery also improved hearts acutely during both perfusion reperfusion periods. acute reduced actions improve after ischemia. conclude that periods availability, endogenous plays a protective role effectively buffering increase blood renal injury contributes lowering tissue model severe hypertension end-organ damage.