Effects of methamphetamine on sexual performance and compulsive sex behavior in male rats
作者： Karla S. Frohmader , Katherine L. Bateman , Michael N. Lehman , Lique M. Coolen
DOI: 10.1007/S00213-010-1930-8
关键词: Arousal 、 Psychiatry 、 Psychology 、 Physiology 、 Sexual function 、 Substance abuse 、 Meth- 、 Compulsive behavior 、 Addiction 、 Methamphetamine 、 Sexual desire
摘要: Methamphetamine (Meth) is a highly addictive psychostimulant associated with enhanced sexual desire, arousal, and pleasure. Moreover, Meth abuse frequently linked the practice of risk behavior increased prevalence human immunodeficiency virus. Currently, there lack studies investigating effects on maladaptive under controlled experimental settings in animal studies. The overall objective current study was to examine various aspects male including sex-seeking behavior. First, dose–response curve (0, 1, 2, 4 mg/kg; s.c.) motivation performance conducted sexually naive experienced rats. Next, (1 mg/kg; inhibition tested using sex aversion conditioning paradigm, which visceral illness induced by lithium chloride (LiCl) paired administration inhibited dose-dependent matter as evidenced decreased percentages males that mated latencies initiate when injected 2 or 4 mg/kg Meth. an acute dose prior following resulted disrupted conditioned These data suggest rats impairs performance. In addition, low doses do not disrupt function may result seeking
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