Repetitive exposure of mice to strong static magnetic fields in utero does not impair fertility in adulthood but may affect placental weight of offspring

作者: Gregor Zaun , Yasmin Zahedi , Stefan Maderwald , Stephan Orzada , Carolin Pütter

DOI: 10.1002/JMRI.24208

关键词: FertilityBiologySpermPregnancyIn uteroImmunologyLitter (animal)AndrologyOffspringEmbryoPrenatal development

摘要: Purpose To investigate the effect of daily exposure in utero to static magnetic fields during prenatal development on germ cell and fertility exposed offspring adulthood. Materials Methods Mice were different field strengths at bore entrance or isocenter 1.5 T 7 MRI systems entire course development. Results In utero-exposed male mice revealed no strength weight testes epididymis sperm count, morphology, fertility. Exposed pregnant female showed reduced terms pregnancy rates litter size, pointing a normal ovarian function. However, placental intrauterine was observed that correlated with decrease embryonic those animals strongest field. This seemed be parent-dependent, since it not embryos fathered by mice. Conclusion Repetitive strong does impair but may have parental-dependent fetal programming regard growth. J. Magn. Reson. Imaging 2014;39:683–690. © 2013 Wiley Periodicals, Inc.

参考文章(40)
Shannon Whirledge, John A. Cidlowski, Glucocorticoids, stress, and fertility. Minerva Endocrinologica. ,vol. 35, pp. 109- 125 ,(2010)
Abigail L. Fowden, Alison J. Forhead, Hormones as epigenetic signals in developmental programming Experimental Physiology. ,vol. 94, pp. 607- 625 ,(2009) , 10.1113/EXPPHYSIOL.2008.046359
Ewald Moser, Freddy Stahlberg, Mark E. Ladd, Siegfried Trattnig, 7-T MR—from research to clinical applications? NMR in Biomedicine. ,vol. 25, pp. 695- 716 ,(2012) , 10.1002/NBM.1794
D.J.P. Barker, The Developmental Origins of Adult Disease Journal of The American College of Nutrition. ,vol. 23, pp. 588- ,(2004) , 10.1080/07315724.2004.10719428
H Möller, D von Cramon, Survey of risks related to static magnetic fields in ultra high field MRI Rofo-fortschritte Auf Dem Gebiet Der Rontgenstrahlen Und Der Bildgebenden Verfahren. ,vol. 180, pp. 293- 301 ,(2008) , 10.1055/S-2008-1027227
Pathik D. Wadhwa, Sonja Entringer, Claudia Buss, Michael C. Lu, The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations Clinics in Perinatology. ,vol. 38, pp. 351- 384 ,(2011) , 10.1016/J.CLP.2011.06.007
Thin Vo, Daniel B. Hardy, Molecular mechanisms underlying the fetal programming of adult disease Journal of Cell Communication and Signaling. ,vol. 6, pp. 139- 153 ,(2012) , 10.1007/S12079-012-0165-3
Charlotte S. Wilhelm-Benartzi, E. Andres Houseman, Matthew A. Maccani, Graham M. Poage, Devin C. Koestler, Scott M. Langevin, Luc A. Gagne, Carolyn E. Banister, James F. Padbury, Carmen J. Marsit, In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta. Environmental Health Perspectives. ,vol. 120, pp. 296- 302 ,(2011) , 10.1289/EHP.1103927
Carolin Hoyer, Miriam A. Vogt, S. Helene Richter, Gregor Zaun, Yasmin Zahedi, Stefan Maderwald, Mark E. Ladd, Elke Winterhager, Ruth Grümmer, Peter Gass, Repetitive exposure to a 7 Tesla static magnetic field of mice in utero does not cause alterations in basal emotional and cognitive behavior in adulthood. Reproductive Toxicology. ,vol. 34, pp. 86- 92 ,(2012) , 10.1016/J.REPROTOX.2012.03.006
Yong-Seok Sohn, Myung-Joon Kim, Ja-Young Kwon, Young-Han Kim, Yong-Won Park, The Usefulness of Fetal MRI for Prenatal Diagnosis Yonsei Medical Journal. ,vol. 48, pp. 671- 677 ,(2007) , 10.3349/YMJ.2007.48.4.671