Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations
作者： Maria Jentink , Janneke , Loane , Jane K Dolk , Helen
关键词: Pregnancy 、 Population 、 Cohort study 、 Obstetrics 、 Offspring 、 Epilepsy 、 Valproic Acid 、 Spina bifida 、 Case-control study 、 Medicine
摘要: Background The use of valproic acid in the first trimester pregnancy is associated with an increased risk spina bifida, but data on risks other congenital malformations are limited. Methods We combined from eight published cohort studies (1565 pregnancies which women were exposed to acid, among 118 major observed) and identified 14 that significantly more common offspring who had received during trimester. then assessed associations between these by performing a case–control study European Surveillance Congenital Anomalies (EUROCAT) antiepileptic-study database, derived population-based congenital-anomaly registries. Registrations (i.e., outcomes included EUROCAT) any compared two control groups, o...
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