Modulation and control of SENP1 phosphorylated modified compound and SIRT3 SUMOylation modified compound and application of SENP1 phosphorylated modified compound and SIRT3 SUMOylation modified compound

摘要: The invention discloses SUMOylation modification which can be carried out at the K288th site of deacetylase SIRT3 dependent on NAD in a mitochondrion as well modulation and control activity SIRT3; meanwhile, SUMO specific protease 1 (SENP1) modulate SIRT3, so that related physiological pathological processes participatingof are modulated controlled; effect SENP1 depends phosphorylated an SENP1S180 site. influence signal path SENP1-SIRT3 shaft metabolism mitochondrion, activation macrophage T cells, tumor immunity growth; therefore, significance onprevention treatment diseases with mitochondria is realized.