Long non‑coding RNA NR2F1‑AS1 facilitates the osteosarcoma cell malignant phenotype via the miR‑485‑5p/miR‑218‑5p/BIRC5 axis.

摘要: Long non‑coding RNA (lncRNA) NR2F1 antisense 1 (NR2F1‑AS1) has been reported to be an oncogene in several cancer types, including osteosarcoma (OS). However, the underlying fundamental molecular mechanism of NR2F1‑AS1 OS remains largely unknown, which present study aimed elucidate. The demonstrated that expression is markedly increased OS, and was shown exert oncogenic functions OS. Further mechanistic studies revealed microRNA (miR)‑485‑5p miR‑218‑5p were direct targets NR2F1‑AS1. More importantly, miR‑485‑5p exhibited low levels negatively correlated with tissues. It then identified baculoviral inhibitor apoptosis repeat‑containing 5 (BIRC5) a target cells. Furthermore, series experiments suggested affects proliferation, migration, invasion cells by regulating BIRC5. Finally, it silencing repressed cell malignant phenotype binding miR‑218‑5p, downregulating BIRC5 expression, suggests NR2F1‑AS1/miR‑485‑5p/miR‑218‑5p/BIRC5 axis could potential for treating