Trifluoromethylation of heterocumulenes with trimethyl(trifluoromethyl)silane in the presence of fluoride ions: synthesis of trifluoroacetamides and trifluorothioacetamides from isocyanates and isothiocyanates
作者： Nataliya V Kirij , Yurii L Yagupolskii , Nataliya V Petukh , Wieland Tyrra , Dieter Naumann
DOI: 10.1016/S0040-4039(01)01764-6
关键词: Medicinal chemistry 、 Chemistry 、 Fluoride 、 Trimethyl(trifluoromethyl)silane 、 Silane 、 Trifluoromethylation 、 Ion 、 Trifluoromethyl 、 Organic chemistry 、 Biochemistry 、 Drug discovery
摘要: Abstract Trimethyl(trifluoromethyl)silane reacts in the presence of fluoride ions with isocyanates and isothiocyanates under mild conditions to give corresponding trifluoroacetamides trifluorothioacetamides high yields.
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