The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test.

摘要: The forced swimming test is a behavioural model developed to predict the efficacy of antidepressant drugs. Few studies have been aimed at evaluating mechanism action antidepressants in test. present study was designed order further evaluate mode test, by using selective agonists and antagonists 5-HT1A 5-HT1B receptor sites. Agonists/antagonists were administered 45 min 30 min, respectively, prior testing. Prior administration 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (1 mg/kg, i.p.) induced anti-immobility effects with tricyclic imipramine (8 noradrenaline uptake inhibitors maprotiline desipramine (16 i.p.), but not fluoxetine citalopram or fluvoxamine i.p.). These antagonised 1-(2-methoxyphenyl)-4-[-(2-phthalimido)butyl]piperazine) (NAN 190) (0.5 On other hand, pretreatment (+/-)-pindolol (32 potentiated serotonin reuptake devoid any activity 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU 24969) enhanced antidepressant-like seem be mediated presynaptic receptors as well postsynaptic receptors. Antidepressant-like seem, on Considering variety 5-HT receptors, it possible that subtypes may participate