Laboratory biomarkers associated with COVID-19 severity and management.
作者： Stephen Keddie , Oliver J Ziff , Michael KL Chou , Rachel L Taylor , Amanda Heslegrave
DOI: 10.1101/2020.08.18.20168807
关键词: ARDS 、 Respiratory failure 、 Medicine 、 Illness severity 、 Coronavirus disease 2019 (COVID-19) 、 Triage 、 Breathing 、 Fraction of inspired oxygen 、 Intensive care medicine 、 Disease severity
摘要: Abstract The heterogeneous disease course of COVID-19 is unpredictable, ranging from mild self-limiting symptoms to cytokine storms, acute respiratory distress syndrome (ARDS), multi-organ failure and death. Identification high-risk cases will enable appropriate intervention escalation. This study investigates the routine laboratory tests cytokines implicated in for their potential application as biomarkers severity, need higher-level care. From analysis 203 samples, CRP, IL-6, IL-10 LDH were most strongly correlated with WHO ordinal scale illness fraction inspired oxygen delivery, radiological evidence ARDS level support (p≤0.001). IL-6 levels ≥3.27pg/ml provide a sensitivity 0.87 specificity 0.64 requirement ventilation, CRP ≥37mg/L 0.91 0.66. Reliable stratification has significant implications on patient triage, resource management potentially initiation novel therapies severe patients.
sci-hub.st 参考文章(15)
Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu, Zhenshun Cheng, Ting Yu, Jiaan Xia, Yuan Wei, Wenjuan Wu, Xuelei Xie, Wen Yin, Hui Li, Min Liu, Yan Xiao, Hong Gao, Li Guo, Jungang Xie, Guangfa Wang, Rongmeng Jiang, Zhancheng Gao, Qi Jin, Jianwei Wang, Bin Cao, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The Lancet. ,vol. 395, pp. 497- 506 ,(2020) , 10.1016/S0140-6736(20)30183-5
Yan Deng, Huiguo Liu, Kui Liu, Jin Shang, Wei Liu, Shuang Wei, Lei Chen, Jing Liu, Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia Chinese Journal of Tuberculosis and Respiratory Diseases. ,vol. 43, pp. 203- 208 ,(2020) , 10.3760/CMA.J.ISSN.1001-0939.2020.03.013
Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li, Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients medRxiv. ,(2020) , 10.1101/2020.02.29.20029520
Dennis McGonagle, Kassem Sharif, Anthony O'Regan, Charlie Bridgewood, The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease. Autoimmunity Reviews. ,vol. 19, pp. 102537- 102537 ,(2020) , 10.1016/J.AUTREV.2020.102537
Tobias Herold, Vindi Jurinovic, Chiara Arnreich, Johannes C. Hellmuth, Michael von Bergwelt-Baildon, Matthias Klein, Tobias Weinberger, Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients medRxiv. ,(2020) , 10.1101/2020.04.01.20047381
Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li, Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019. Clinical Infectious Diseases. ,vol. 71, pp. 1937- 1942 ,(2020) , 10.1093/CID/CIAA449
Francisco Alejandro Lagunas‐Rangel, Venice Chávez‐Valencia, High IL-6/IFN-γ ratio could be associated with severe disease in COVID-19 patients Journal of Medical Virology. ,vol. 92, pp. 1789- 1790 ,(2020) , 10.1002/JMV.25900
Suxin Wan, Qingjie Yi, Shibing Fan, Jinglong Lv, Xianxiang Zhang, Lian Guo, Chunhui Lang, Qing Xiao, Kaihu Xiao, Zhengjun Yi, Mao Qiang, Jianglin Xiang, Bangshuo Zhang, Yongping Chen, Cailiang Gao, Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. British Journal of Haematology. ,vol. 189, pp. 428- 437 ,(2020) , 10.1111/BJH.16659
Fang Liu, Lin Li, MengDa Xu, Juan Wu, Ding Luo, YuSi Zhu, BiXi Li, XiaoYang Song, Xiang Zhou, Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. Journal of Clinical Virology. ,vol. 127, pp. 104370- 104370 ,(2020) , 10.1016/J.JCV.2020.104370
Ben Goldacre, , Elizabeth Williamson, Alex J Walker, Krishnan Bhaskaran, Seb Bacon, Chris Bates, Caroline E Morton, Helen J Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Brian MacKenna, Laurie Tomlinson, Ian J Douglas, Christopher T Rentsch, Rohini Mathur, Angel Wong, Richard Grieve, David Harrison, Harriet Forbes, Anna Schultze, Richard Croker, John Parry, Frank Hester, Sam Harper, Raf Perera, Stephen Evans, Liam Smeeth, OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients medRxiv. ,(2020) , 10.1101/2020.05.06.20092999