Trophoblast immune receptors in maternal-fetal tolerance.

摘要: During pregnancy, interactions between maternal immune cells and fetal trophoblast of the placenta would seemingly lead to disaster, as are semi-allogeneic should trigger rejection by response. A fundamental immunologic question pregnancy posed Sir Peter Medawar centers on how disaster is averted. It becoming clear that many different mechanisms act during gestation render system tolerant fetus. These include, among others, restricted major histocompatibility complex (MHC) protein expression, presence immunosuppressive B7 family members, immunomodulatory adhesion molecules, expression apoptosis-inducing proteins, complement regulatory proteins. Understanding maternal-fetal tolerance has clinically important implications for fields reproduction, autoimmunity transplantation. Herein discussed which protected from cell attack. Specifically role surface proteins at interface considered.