Platelet Glycoprotein IIIa PlA Polymorphism, Fibrinogen, and Platelet Aggregability The Framingham Heart Study
作者： DaLi Feng , Klaus Lindpaintner , Martin G. Larson , Christopher J. O’Donnell , Izabella Lipinska
关键词: Fibrinogen 、 Framingham Risk Score 、 Medicine 、 Receptor 、 Genotype 、 Platelet 、 Offspring 、 Framingham Heart Study 、 Fibrinogen binding 、 Endocrinology 、 Immunology 、 Internal medicine
摘要: Background— Recent data suggest that the PlA2 allele of platelet glycoprotein IIIa receptor may be a genetic risk factor for cardiovascular disease. We previously reported was associated with increased aggregability, as indicated by lower epinephrine threshold concentrations. Paradoxically, however, it has been PlA2-positive platelets have reduced fibrinogen binding. Because mediates we hypothesized plasma levels interact PlA genotype in modulating aggregability. Methods and Results— Glycoprotein genotype, level, aggregability were ascertained 1340 subjects enrolled into Framingham Offspring Study. Platelet evaluated Born method. Higher epinephrine-induced aggregation (P=0.002) trend ADP-induced (P=0.07). The effect specific, however...
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