GLC assay for 5-fluorouracil in biological fluids.
作者： Jordan L. Cohen , Patrick B. Brennan
关键词: Biological fluids 、 Drug 、 Extraction (chemistry) 、 Silylation 、 Aqueous solution 、 Chromatography 、 Free drug 、 Fluorouracil 、 Chemistry 、 Pharmacokinetics
摘要: A rapid, sensitive GLC method of analysis for 5-fluorouracil was developed to follow the disposition drug in patients on therapy. The free is removed from aqueous biological samples a single extraction step, derivatized by silylation, and chromatographed using flame-ionization detection. An internal standard utilized quantitate results. procedure (0.2 mcg./ml. plasma), specific intact molecule, suitable support pharmacokinetic studies animals humans.
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