Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis.

摘要: Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although in a given tumour type, oncogenic mutations are selectively observed only one of the acquisition transformed phenotype has been shown to require contribution normal products other genes. Here we demonstrate that K-Ras promotes activation wild-type H- N-Ras. This is mediated by K-Ras-dependent allosteric stimulation Sos confers growth advantage harbouring cancer cells. These findings underscore complementary functions Ras identify potential new targeting strategy for Ras-driven tumours.