Asthma in inner city children: recent insights: United States.

作者: Cullen M. Dutmer , Haejin Kim , Daniel A. Searing , Edward M. Zoratti , Andrew H. Liu

DOI: 10.1097/ACI.0000000000000423

关键词: AsthmaInner cityPsychological interventionInner CitiesIntensive care medicineMedicineExacerbationAsthma careAsthma severityAsthma phenotypes

摘要: PURPOSE OF REVIEW Children living in US inner cities experience disparate burdens of asthma, especially severity, impairment, exacerbations, and morbidity. Investigations seeking to better understand the factors mechanisms underlying asthma prevalence, exacerbation children these communities can lead interventions that narrow disparities potentially benefit all with asthma. This update will focus on recent (i.e. late 2016-2017) advances understanding city children. RECENT FINDINGS Studies published past year expand exacerbation, outcomes guidelines-based management at-risk children, including: phenotypes are severe difficult-to-control; key environmental determinants severity exacerbations (e.g. allergy-mediated susceptibility rhinovirus); importance schools as a place for provocative exposures mouse allergen, nitrogen dioxide) well where care be improved; development validation clinically useful indices gauging predicting exacerbations. SUMMARY These studies provide trove actionable findings improve

参考文章(36)
Stephen J. Teach, Michelle A. Gill, Alkis Togias, Christine A. Sorkness, Samuel J. Arbes, Agustin Calatroni, Jeremy J. Wildfire, Peter J. Gergen, Robyn T. Cohen, Jacqueline A. Pongracic, Carolyn M. Kercsmar, Gurjit K. Khurana Hershey, Rebecca S. Gruchalla, Andrew H. Liu, Edward M. Zoratti, Meyer Kattan, Kristine A. Grindle, James E. Gern, William W. Busse, Stanley J. Szefler, Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. The Journal of Allergy and Clinical Immunology. ,vol. 136, pp. 1476- 1485 ,(2015) , 10.1016/J.JACI.2015.09.008
Jacqueline A. Pongracic, Cynthia M. Visness, Rebecca S. Gruchalla, Richard Evans, Herman E. Mitchell, Effect of mouse allergen and rodent environmental intervention on asthma in inner-city children Annals of Allergy Asthma & Immunology. ,vol. 101, pp. 35- 41 ,(2008) , 10.1016/S1081-1206(10)60832-0
Richard Evans, Peter J. Gergen, Herman Mitchell, Meyer Kattan, Carolyn Kercsmar, Ellen Crain, John Anderson, Peyton Eggleston, Floyd J. Malveaux, H.James Wedner, A randomized clinical trial to reduce asthma morbidity among inner-city children: results of the National Cooperative Inner-City Asthma Study. The Journal of Pediatrics. ,vol. 135, pp. 332- 338 ,(1999) , 10.1016/S0022-3476(99)70130-7
Jeremy J. Wildfire, Peter J. Gergen, Christine A. Sorkness, Herman E. Mitchell, Agustin Calatroni, Meyer Kattan, Stanley J. Szefler, Stephen J. Teach, Gordon R. Bloomberg, Robert A. Wood, Andrew H. Liu, Jacqueline A. Pongracic, James F. Chmiel, Kathleen Conroy, Yadira Rivera-Sanchez, William W. Busse, Wayne J. Morgan, Development and validation of the Composite Asthma Severity Index—an outcome measure for use in children and adolescents Journal of Allergy and Clinical Immunology. ,vol. 129, pp. 694- 701 ,(2012) , 10.1016/J.JACI.2011.12.962
Sharon K. Ahluwalia, Roger D. Peng, Patrick N. Breysse, Gregory B. Diette, Jean Curtin-Brosnan, Charles Aloe, Elizabeth C. Matsui, Mouse allergen is the major allergen of public health relevance in Baltimore City The Journal of Allergy and Clinical Immunology. ,vol. 132, pp. 830- 835 ,(2013) , 10.1016/J.JACI.2013.05.005
Ivana V. Yang, Brent S. Pedersen, Andrew Liu, George T. O'Connor, Stephen J. Teach, Meyer Kattan, Rana Tawil Misiak, Rebecca Gruchalla, Suzanne F. Steinbach, Stanley J. Szefler, Michelle A. Gill, Agustin Calatroni, Gloria David, Corinne E. Hennessy, Elizabeth J. Davidson, Weiming Zhang, Peter Gergen, Alkis Togias, William W. Busse, David A. Schwartz, DNA methylation and childhood asthma in the inner city. The Journal of Allergy and Clinical Immunology. ,vol. 136, pp. 69- 80 ,(2015) , 10.1016/J.JACI.2015.01.025
Peggy S. Lai, William J. Sheehan, Jonathan M. Gaffin, Carter R. Petty, Brent A. Coull, Diane R. Gold, Wanda Phipatanakul, School Endotoxin Exposure and Asthma Morbidity in Inner-city Children Chest. ,vol. 148, pp. 1251- 1258 ,(2015) , 10.1378/CHEST.15-0098
William W Busse, Robert F Lemanske, James E Gern, Role of viral respiratory infections in asthma and asthma exacerbations The Lancet. ,vol. 376, pp. 826- 834 ,(2010) , 10.1016/S0140-6736(10)61380-3
Jeremy Wildfire, Gordon R. Bloomberg, Carolyn M. Kercsmar, Andrew H. Liu, Melanie M. Makhija, Elizabeth Matsui, Wayne Morgan, George O'Connor, William W. Busse, Stephen J. Teach, Peter J. Gergen, Stanley J. Szefler, Herman E. Mitchell, Agustin Calatroni, Seasonal risk factors for asthma exacerbations among inner-city children The Journal of Allergy and Clinical Immunology. ,vol. 135, pp. 1465- 1473 ,(2015) , 10.1016/J.JACI.2014.12.1942
Yury A. Bochkov, James E. Gern, Rhinoviruses and Their Receptors: Implications for Allergic Disease Current Allergy and Asthma Reports. ,vol. 16, pp. 30- 30 ,(2016) , 10.1007/S11882-016-0608-7