Synthesis, Self-Assembly, and Drug Delivery Characteristics of Poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) Copolymers with Variable Compositions of Hydrophobic Blocks: Combining Chemistry and Microfluidic Processing for Polymeric Nanomedicines.

摘要: The synthesis, characterization, and self-assembly of a series biocompatible poly(methyl caprolactone-co-caprolactone)-b-poly(ethylene oxide) amphiphilic block copolymers with variable MCL contents in the hydrophobic are described. Self-assembly gives rise to polymeric nanoparticles (PNPs) cores that decrease crystallinity as content increases, their morphologies sizes show nonmonotonic trends content. PNPs loaded anticancer drug paclitaxel (PAX) give vitro PAX release rates MCF-7 GI50 (50% growth inhibition concentration) values increases. We also for selected microfluidic manufacturing at flow rate enables further control enhances antiproliferation potency. These results indicate more effective specific delivery possible through tangential efforts combining polymer synthesis manufacturing.