Poly(ADP-ribose) polymerase activity in different pathologies--the link to inflammation and infarction.
作者： Sascha Beneke
DOI: 10.1016/J.EXGER.2008.04.008
关键词: Polymerase 、 Biochemistry 、 Enzyme 、 DNA repair 、 NAD+ kinase 、 DNA damage 、 Ribose 、 Poly ADP ribose polymerase 、 Programmed cell death 、 Biology
摘要: DNA repair and aging are two phenomena closely connected to each other. The poly(ADP ribosyl)ation reaction has been implicated in both of them. Poly(ADP ribose) was originally discovered as an enzymatic product after damage. Soon it became evident that is necessary for regulation different pathways. Also, evidence accumulated formation capacity at least corre lated with the life span mammalian species. As a NAD + consuming process, can lead cell death by energy depletion. This finding opened area investigation polymerase activity polymer pathologies. review provides introduction into wide complex field pathologies regards reg ulation, inflammation resulting tissue
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